Search Database Collection

 

Choose parameters to search by

in organism:

verbatim:

Result for the search by Unspecified:

Total record(s): 1817

Fusion Proteins
ChiPPI and
Interactors
Pathway Breakpoints Cancers Literature Instances ChiTaRS
[NCBI] [UniProt]
123456
ROS1 + EZR
HAS00004014
path size: 107
closeness: 0.60
stress: 10.00
betweenness: 0.015
shared neighbors: 2.056
shortest path: 2.0
clustering coeff: 0.010
t(6;6)(q22;q25)
inv(6)(q22q25)
-

Interactions:
In mice, the FIG-ROS1 fusion gene has been shown to promote the formation of astrocytomas when ectopically expressed in the basal ganglia, and the EZR-ROS1 fusion gene has been shown to promote lung adenocarcinoma when ectopically expressed in lung epithelium

Extended Pubmeds:
22327623 ; 23426121 ; 24469108 ; 25079552 ; 25204415 ;

[J7M2B1]
Check
RRP15 + ACBD6
HAS00004015
path size: 105
closeness: 0.65
stress: 10.00
betweenness: 0.020
shared neighbors: 1.714
shortest path: 2.0
clustering coeff: 0.006
t(1;1)(q25;q41)
Adenocarcinoma-Check
ETV1 + ACSL3
HAS00004010
path size: 136
closeness: 0.30
stress: 12.00
betweenness: 0.020
shared neighbors: 2.515
shortest path: 4.0
clustering coeff: 0.026
t(2;7)(q36;p21.3)
t(2;7)(q34;p21.3)
t(2;7)(q36;p21)
Adenocarcinoma

Interactions:
Expression of ACSL3 was also elevated in a panel of ‘androgen-sensitive' (LAPC-4, LNCaP, MDA PCa2a, MDA PCa2b, and 22Rv1) versus ‘androgen-insensitive' (PPC1, PC3, and DU145) prostate cancer cell line

18594527

Attard G, Clark J, Ambroisine L, Mills IG, Fisher G, Flohr P, Reid A, Edwards S, Kovacs G, Berney D, Foster C, Massie CE, Fletcher A, De Bono JS, Scardino P, Cuzick J. Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer / Br J Cancer., v.99, issue 2, July, 2008, pp.314-20
Sentences:
The presence of the ACSL3:ETV1 fusion was confirmed in this specimen by RT–PCR using 5′-ACSL3 and 3′-ETV1 primers (Figure 3B, C) and co-localisation by FISH of BAC probes corresponding to 5′-ACSL3 sequences (green) and 3′-ETV1 sequences (red) (Figure 3D, panel iii).

Extended Pubmeds:
16467868 ;

Check
ACTB + GLI1
HAS00004012
path size: 80
closeness: 0.30
stress: 10.00
betweenness: 0.040
shared neighbors: 2.125
shortest path: 2.0
clustering coeff: 0.017
t(7;12)(p22;q13)
Vascular and Perivascular tumor

Interactions:
We found that co-expression of Dyrk1 and Gli1 strongly induced Gli1-dependent gene transcription in the presence of the 3′GliBS-Luc reporter construct, but not in the presence of the mutant reporter construct, m3′GliBS-Luc

Check
ACTG1 + MEPCE
HAS00004310
path size: 85
closeness: 0.52
stress: 8.00
betweenness: 0.000
shared neighbors: 1.812
shortest path: 2.0
clustering coeff: 0.067
---
[BI061732]
Check
ACTN4 + MLL
HAS00004330
path size: 30
closeness: 1.00
stress: 10.00
betweenness: 0.150
shared neighbors: 1.067
shortest path: 2.0
clustering coeff: 0.000
t(11;19)(q23;q13)
leukemia

Interactions:
Recently, Ehrlicher and Pollak et al. demonstrated that in FSGS, a K255E mutation in ACTN4 changes the cellular biological properties in which increasing the affinity for actin increases cellular forces and work and decreases cellular movement

Extended Pubmeds:
19262598 ; 23628958 ;

[B3W6H3]
Check
MLL + AFF1
HAS00004340
path size: 25
closeness: 0.00
stress: 0.00
betweenness: 0.000
shared neighbors: 0.000
shortest path: 0.0
clustering coeff: 0.000
t(4;11)(q21;q23)
ins(4;11)(q21;q23q23)
ins(11;4)(q23;q21q24)
del(6)(q?)
del(9)(p?)
der(11)(q23)
del(13)(q?)
ins(4;11)(q21;q13q23)
ins(11;4)(q23;q21q31)
leukemia

Interactions:
Hybridization of the MLL/AF4 probe combination to pure SEM cells resulted in 87% of the cells displaying the expected AF4x3/MLLx3/AF4 con MLLx2 hybridization pattern

Extended Pubmeds:
11167741 ; 11420702 ; 11930009 ; 11943339 ; 12750700 ; 12791662 ; 12885467 ; 12972812 ; 1423625 ; 15257548 ; 15650057 ; 16123216 ; 16341046 ; 16424875 ; 16511515 ; 17039234 ; 17039237 ; 17287854 ; 17407135 ; 17410185 ; 19141862 ; 19144982 ; 19459927 ; 1991161 ; 20016535 ; 20107154 ; 21354057 ; 21935650 ; 23349309 ; 23628958 ; 24415536 ; 3496135 ; 7579356 ; 7748964 ; 7794749 ; 8161794 ; 8162575 ; 8180386 ; 8219184 ; 8358709 ; 8378328 ; 8414518 ; 8443374 ; 8506309 ; 8703835 ; 9250788 ; 9680349 ; 9731046 ;

[Q0ZHH1]
[Q8NI09]
[Q8NI10]
[Q8TD97]
[Q8TD98]
Check
AGPAT5 + MCPH1
HAS00004350
path size: 64
closeness: 0.68
stress: 8.00
betweenness: 0.050
shared neighbors: 1.312
shortest path: 1.0
clustering coeff: 0.000
--

Interactions:
Several genes involved in fusions have been reported to be fused or rearranged in other cases–AGPAT5, NOTCH2, PUM1, SEC22B, SGK1 and TRERF1 (all early or unclassified), while several are mutated at sequence level, notably SYNE2

23762276

Nemoto N, Nemoto N, Suzukawa K, Suzukawa K, Shimizu S, Shimizu S, Shinagawa A, Shinagawa A, Takei N, Takei N, Taki T, Taki T, Hayashi Y, Hayashi Y, Kojima H, Kojima H, Kawakami Y, Kawakami Y, Nagasawa T, Nagasawa T. The relative timing of mutations in a breast cancer genome / PLoS One, v.8, issue 6, June, 2013, pp.e64991
Sentences:
Seven of the twelve fusion transcripts were classified as before endoreduplication; two, CTCF-SCUBE2 and BC041478-EXOSC10 were classified later. AGPAT5-MCPH1 and SUSD1-ROD1/PTBP3 and KLK5-CDH23 were undetermined, as their allelic copy number could not be resolved by array CGH or FISH. These structural rearrangements gave rise to at least twelve expressed fusion transcripts, confirmed by RT-PCR and Sanger sequencing: RGS22-SYCP1, CTAGE5-SIP1, PLXND1-TMCC1, SEC22B-NOTCH2, KLK5-CDH23, BC041478-EXOSC10, AGPAT5-MCPH1, SUSD1-ROD1/PTBP3, SGK1-SLC2A12, RHOJ-SYNE2, PUM1-TRERF1 and CTCF-SCUBE2

Check
BRAF + AGTRAP
HAS00004390
path size: 110
closeness: 0.70
stress: 10.00
betweenness: 0.100
shared neighbors: 1.109
shortest path: 1.0
clustering coeff: 0.010
t(1;7)(p36;q34)
Adenocarcinoma

Interactions:
The finding of mutated RAF genes in prostate cancer is consistent with a previous observation that oncogenic BRAFV600E can initiate prostate cancer in mouse models16 and may have major implications for therapy

Extended Pubmeds:
20526349 ;


[HM053972]
[D7RF68]
Check
BRAF + AKAP9
HAS00004370
path size: 40
closeness: 0.50
stress: 7.50
betweenness: 0.000
shared neighbors: 1.600
shortest path: 1.5
clustering coeff: 0.029
inv(7)(q21q34)
inv(7)(?)
Adenocarcinoma

Interactions:
The large amplification on chromosomes 7 and 12 could potentially activate the RAS-RAF-MEK pathway by amplification of the BRAF gene located on chromosome 7 or amplification of KRAS located on chromosome 12


[AY803272]
[Q5IBP5]
Check

Visitors ( today / unique / total from 27.06.2016 ): 11 / 654 / 19101